https://www.selleckchem.com/pr....oducts/incb28060.htm
In an early stage of Alzheimer's disease (AD), before the formation of amyloid plaques, neuronal network hyperactivity has been reported in both patients and animal models. This suggests an underlying disturbance of the balance between excitation and inhibition. Several studies have highlighted the role of somatic inhibition in early AD, while less is known about dendritic inhibition. In this study we investigated how inhibitory synaptic currents are affected by elevated Aβ levels. We performed whole-cell patch clamp recordings of CA1
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