https://www.selleckchem.com/pr....oducts/pi3k-hdac-inh
The role of geographical variations in these factors may provide some possible clues and basis for tailoring site-specific intervention strategies.PI3K/Akt/mTOR signaling pathway activity is highly elevated in glioblastoma (GBM). Although rapamycin is known to inhibit this pathway, GBM patients are resistant to rapamycin monotherapy. This may be related to mutations of tumor suppressor phosphatase and tensin homolog (PTEN). Here, we show that higher expression of E3 ligase Smad ubiquitylation regulatory factor 1 (Smurf1) i
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