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Medication For ADHD - What Are the Side Effects? with ADHD notice a decrease in symptoms when they use medication. Each person's reaction to drugs is different, and side effects are sometimes problematic. Methylphenidate is a stimulant. It works by raising levels of a chemical in the brain that assists in controlling the behavior and attention. Stimulant medication Stimulant drugs improve attention and concentration in 70 to 80percent of children and adults who take t