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To clarify the scientific evidence, we performed a systematic analysis and differing meta-analyses in connection with prospective part of supplement D in ALS. Techniques We performed a systematic breakdown of clinical trials, cohorts, and case-control researches retrieved from PubMed, EMBASE, and Cochrane databases reporting supplement D levels as a putative biomarker for ALS diagnosis or prognosis or the effect of supplement D supplementation in ALS clients. As much as possible, information were pooled using a ra