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Both anti-CCP cut-offs conferred an approximate fourfold increased risk of future IA (HR 4.09 and HR 3.95, p0.01).These conclusions support that aAb evaluating in a non-clinical setting can determine RA-related aAb+ individuals, as well as levels and combinations of aAbs that are associated with greater risk for future IA. Tracking when it comes to development of IA in aAb+ people and similar aAb screening techniques in at-risk communities may re