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Moreover, USP48 was conspicuously overexpressed in HNSCC cells and capable of binding with miR-299-5p. LINC00467 could upregulate USP48 expression via sponging miR-299-5p. In the end, rescue assays proved that USP48 overexpression could compensate for suppressive effects on HNSCC progression mediated by LINC00467 deficiency. CONCLUSIONS LINC00467 enhances HNSCC progression by serving as a sponge of miR-299-5p to increase USP48 expression. This article is protected by copyright. All rights reserved.Soft and flexible two-dimensional (2D)