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and 51-80 years 2.6 (1.2-7.3). Absolute values women aged 18-25 years 112.0 (40.0-153.1), 26-50 years 67.0 (26.7-138.3), and 51-80 years 40 (18.6-92.; and men aged 18-25 years 71.5 (32.1-166.7), 26-50 years 61.5 (29.9-188.7), and 51-80 years 36 (13.5-81.7). The low sex*age interaction confi rms these differences occur in both men and women. Values decrease with age, with a more abrupt fall starting at 50 years. CONCLUSIONS Estimated reference values were determined for absolute values and relative proportions of double-negative T lympho