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Attrition is a major obstacle for lifestyle interventions sustained for the medium-to-long term and can have significant consequences on the internal validity of a trial. When the degree of attrition differs between active and control arms this is termed differential attrition and is an important consideration during initial stages of trial planning. The primary research question of this study was what is the differential attrition between treatment arms in lifestyle interventions for prevalent chronic diseases? We performed a systemat