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This review aims to provide an updated report in regards to the correlation between vaccines and anaphylaxis and the related risk in the population. Initial reports showed higher incidence of anaphylaxis following messenger RNA COVID-19 vaccines compared with 'routine' vaccinations, likely influenced by the great attention paid to these 'new' vaccines. However, anaphylaxis has still to be considered quite rare and its incidence will be systematically reconsidered in the light of additional data collected. Adverse reactions to vaccines ar