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01). RAW 264.7 cells provide a cell model for studying the mechanisms underlying GSDMD-mediated macrophage death. gsdmd-/-RAW 264.7 cells provide a cell model for studying the mechanisms underlying GSDMD-mediated macrophage death. To investigate the effects of restrictive fluid management in patients with severe traumatic brain injury (sTBI). Between January, 2019 and June, 2020, we randomly assigned 51 postoperative patients (stay in the ICU of no less than 7 days) with sTBI into treatment group ( =25) with restrictive fluid management a