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Similar numbers of patients were males in both groups (male/female 50/53 and male/female 46/41). Two (2.3%) patients who received lactulose and antibiotic therapy developed infection during the course of hospitalization, compared with 10 (9.7%) patients who received antibiotic therapy alone ( = 0.04, Fisher exact test). Administration of lactulose may reduce the incidence of -related diarrhea among hospitalized adult patients receiving antibiotics. Administration of lactulose may reduce the incidence of C. difficile-related diarrhea among