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Clinical diagnostic criteria of familial hypercholesterolemia (FH) in Japan include LDL cholesterol≥180mg/dL, Achilles tendon thickness≥9.0mm, and family history. However, few data exist regarding its validation. A series of 680 participants, with a mean LDL cholesterol of 175mg/dL were enrolled at Kanazawa University Hospital between 2006 and 2018. All had full assessments of, LDL cholesterol, Achilles tendon X-rays, family history records, and genetic analysis of FH-associated genes ( , , and ). The area under the curve (AUC) of receiver
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