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535; 95% CI 1.892-10.870; p = 0.001). This association remained after adjusting for the degree of carotid stenosis (HR = 3.491; 95% CI 1.410-8.646; p = 0.007). IPN was an independent predictor of stroke recurrence in patients with a recent ischemic stroke and carotid atherosclerosis. In predicting stroke recurrence, IPN may be an earlier indicator than carotid stenosis and may help stratify the risk of stroke recurrence. IPN was an independent predictor of stroke recurrence in patients with a recent ischemic stroke and carotid atheroscler