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Cerebral cavernous malformations (CCM) in deep eloquent areas present a surgical challenge. Laser interstitial thermal therapy (LITT) may present itself as a safe minimally invasive treatment option. To systematically review the indications, safety, and outcomes of LITT for CCM. Electronic databases were searched from inception to October 7, 2021 for articles with CCM and LITT keywords. Studies describing CCMs treated with LITT were included. A total of 32 patients with CCMs in lobar (79%), basal ganglia (12%), and brainstem (9%) locatio