https://www.selleckchem.com/pr....oducts/salvianolic-a
Using targeted biosensors, we mapped the relative inhibition of NK1R signaling as the receptor moved into the cell. Span selectively inhibited cell surface signaling, whereas Span-Chol partitioned into endosomal membranes and blocked endosomal signaling. In a preclinical model of pain, Span-Chol caused prolonged antinociception (9 h), which is attributable to a three-pronged mechanism of action increased local concentration at membranes, a prolonged decrease in NK1R endocytosis, and persistent inhibition of signaling from
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