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onal dysregulation because of HD mutations, including bidirectional dysregulation of many cell type identity genes that may be driven by partial loss-of-function of the polycomb repressive complex (PRC). Identifying these regulators of transcriptional dysregulation in HD can be leveraged to design novel disease-modifying therapeutics.This is the story of a search for a cortical map of auditory space. The search began with a study that was reported in the first issue of the Journal of Neuroscience (Middlebrooks and Pettigrew, 1981, 1107-