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C. Goodwin, A. Verma, C. P. Arevalo, et al., medRxiv, 2020, https//doi.org/10.1101/2020.11.06.20227215; S. M. Kissler, C. Tedijanto, E. Goldstein, Y. H. Grad, and M. Lipsitch, Science 368860-868, 2020, https//doi.org/10.1126/science.abb5793).Influenza vaccines have traditionally been tested in naive mice and ferrets. However, humans are first exposed to influenza viruses within the first few years of their lives. Therefore, there is a pressing need to test influenza virus vaccines in animal models that have been previously exposed to inf