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Urinary tract infections (UTIs) are often treated with antibiotics and are a source of antibiotic overuse. To systematically review randomised controlled trials (RCTs) of adult women in the community with a history of recurrent UTIs and who use methenamine hippurate prophylactically. Systematic review of women in the UK, Australia, Norway, and US (aged ≥18 years) with recurrent UTIs receiving methenamine hippurate against placebo or no treatment, and antibiotics. The authors searched three databases, clinical trial registries, and perform