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By characterizing drug kind and concentration, this methodology can be employed to develop a dependable complementary examination way for meconium toxicology screens.Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) may play an important role in major problems. Preclinical research shows that PACAP38 modulates trigeminal nociceptive activity mainly through PAC1 receptors while medical researches report that plasma levels of PACAP38 tend to be elevated in natural attacks of cluster