https://ros1signal.com/index.p....hp/sophisticated-imp
While ineffective erythropoiesis has long been named an integral factor to anemia in thalassemia, its role in anemia of sickle-cell condition (SCD) will not be critically explored. Using in vitro and in vivo derived individual erythroblasts we evaluated the extent of ineffective erythropoiesis in SCD. Modeling the bone marrow hypoxic environment, we discovered that hypoxia induces loss of sickle erythroblasts beginning during the polychromatic phase, favorably selecting cell
Like
Comment
Share
