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e volume, alleviating symptoms of BPH, and increasing concentrations of circulating FT. Using mechanically skinned rat muscle fibres, we investigated (i) transverse tubular-system (T-system) excitability after high-intensity contractions, and (ii) the mechanisms underlying the fatigue-induced alteration of the T-system excitability. T-system excitability estimated by using skinned fibres, which is highly regulated by T-system Na -K -ATPase, was decreased after muscle contractions, but was fully restored by treatment with dithiothreitol. Th
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