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3% of patients in Group I and in 53.3% of patients in Group II ( = 0.581). Postoperatively, in the intensive care unit, 26.7% of the patients in Group I and 71.7% in Group II had AF ( 0.001). At the time of discharge, 30% of patients in Group I and 73.3% of patients in Group II had AF ( 0.001). A single combined prophylactic intraoperative dose of i.v. amiodarone and MgSO decreased postbypass arrhythmia in comparison to the placebo group in patients of MVR surgery. A single combined prophylactic intraoperative dose of i.v.