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These findings highlight the need to understand the temporal and spatial components of thermotolerance variation better, including plasticity and rapid seasonal selection, and the potential for this variation to affect species responses to climate change. With summers becoming longer and increasing winter nighttime temperatures, we expect increasing tropicalization of species thermal tolerances in both space and time.We report three babies from two families with a severe lethal form of congenital cutis laxa. All three had redundant and
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