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Customers with preoperative systemic therapy, that is, chemotherapy and radiotherapy performed ahead of surgery, had less fibrosis and discomfort, and showed greater satisfaction regarding the breast preservation. Preoperative systemic treatment also led to much better survival of this patients. Preoperative systemic therapy is beneficial to alleviate side-effects and improve the breast conservation, therapy result, and survival of LABC patients.Preoperative systemic tr