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All compounds had been synthesized and evaluated in biological assay showing the inhibitory task from 28% to 82% compared to SB202190 and binding mode analysis uncovered that the hydrogen-bond communications with deposits (Met109, Val3 were a key point in inhibitor binding. Compound 5g clearly proved the greatest inhibitory action and may be additional used for designing newer anti-cytokine agents and p38α MAP kinase possibly inhibitory action.An efficient gene distribution sys
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