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Clinically, human arterial blood directly sampled from the ischemic cerebral circulation indicated local shedding of platelet CD84. Moreover, high platelet CD84 expression levels were associated with poor outcome in patients with stroke. These results establish CD84 as a critical pathogenic effector and thus a potential pharmacological target in ischemic stroke. These results establish CD84 as a critical pathogenic effector and thus a potential pharmacological target in ischemic stroke.Purpose The larynx plays a role in swallowing, respir