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These findings suggest that VEGFD supplementation might be a novel, clinically applicable approach for neuronal and vascular protection. © 2019 The Author(s).Gene therapy with adeno-associated virus (AAV)-based vectors shows great promise for the gene therapeutic treatment of a broad array of diseases. In fact, the treatment of genetic diseases with AAV vectors is currently the only in vivo gene therapy approach that is approved by the US Food and Drug Administration (FDA). Unfortunately, pre-existing antibodies against AAV severely lim