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These adhere to the axon, focusing voltage-dependent sodium channels at nodes of Ranvier and patterning the encompassing axon into distinct molecular domain names. The indicators in charge of creating and keeping the complex framework of paranodal myelin are badly grasped. Right here, we test the hypothesis that the planar cell polarity determinant Vangl2 organizes paranodal myelin. We reveal that Vangl2 is targeted at paranodes and that, after conditional knockout
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