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Nevertheless, manufacturing with this Mega Dalton-sized molecular machine, with over a hundred subunits, additionally imposes a significant metabolic price. Here we show that the chromosomal virB operon, which encodes the structural genetics with this T4SS in X. citri, is managed because of the conserved international regulator CsrA. Relieving CsrA repression from the virB operon produced a greater number of T4SSs in the mobile envelope and an increased performance in contact-depend