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The results indicate that under a high initial quantum concentration (e.g., 0.3 q/m3) and no protective measures, SS WR control underestimates the required ventilation rate. The ventilation energy consumption of NSS control is up to 2.5 times as high as that of the SS control.Mathematical programming and meta-heuristics are two types of optimization methods. Meta-heuristic algorithms can identify optimal/near-optimal solutions by mimicking natural behaviours or occurrences and provide benefits such as simplicity of execution, a few para