https://www.selleckchem.com/products/mt-802.html
Established sorafenib-resistant Huh1 and Huh7 cell lines showed reduced expression of Capicua without mutations. Immunohistochemical analysis revealed that HCC patients with low Capicua expression showed poor overall survival. Microarray analysis showed that the CIC gene signature could predict the preventive effect of adjuvant sorafenib treatment on HCC recurrence. Intriguingly, although CIC knockdown induced sorafenib-resistance in HCC cell lines, regorafenib suppressed growth of sorafenib-resistant Capicua-inactivated HCC cells and in
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