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Dysbiosis, an imbalance of abdominal flora, could cause severe circumstances such obesity, disease, and psychoneurological problems. One reason behind dysbiosis is irritation. Ulcerative enteritis is a side aftereffect of non-steroidal anti-inflammatory drugs (NSAIDs). To counteract this complication, we proposed the concurrent use of histamine H2 receptor antagonists (H2RA), and we examined the consequence on the abdominal flora. We generated a murine type of NSA