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Making use of whole-genome sequencing of zebrafish mutants isolated in an unbiased genetic display, we identified the palmitoyltransferase Huntingtin interacting protein 14 (Hip14) as a crucial regulator of habituation discovering. We prove that Hip14 regulates depression of physical inputs onto an identified hindbrain neuron and supply evidence that Hip14 palmitoylates the Shaker-like K+ voltage-gated station subunit (Kv1.1), thereby controlling Kv1.1 subcellular localization. Additionally, we show that