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The in situ surface endothelialization was evaluated via implanting Au-MCP@NPs into rat aortas. The in vivo results demonstrated that this smart Au-MCP@NP surface could lead to the localized upregulation of ZNF580 protein and accelerate in situ endothelialization. This smart MMP-responsive gene delivery surface provided a promising and powerful strategy for enhanced in situ endothelialization of blood-contacting medical devices.Metal contacts play a fundamental role in nanoscale devices. In this work, Schottky metal contacts in monolayer
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