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Diabetes includes a team of metabolic disorders characterized by hyperglycemia that cause the development of life-threatening complications. The impacts of main-stream medical therapy are usually restricted consequently they are followed closely by many unwanted effects, including hypoglycemia, obesity, and injury to the liver and renal. Recently, a few studies have shown that EVs introduced by stem cells and resistant cells can regulate gene expression in the person cells, thus supplying a strategy to deal with diabete