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We examined associations among irritability (e.g., a feeling of agitation), inflammatory biomarkers, and depression during chemotherapy. Forty-four nonmetastatic breast cancer patients were assessed at baseline and after 3 months of chemotherapy on The Irritability Scale-Initial Version (TISi), severity and new onset of depressive symptoms using the Hamilton Depression Rating Scale (HAM-D), and serum levels of high-sensitivity C-reactive protein (hs-CRP) and interleukin 6 (IL-6). At baseline, hs-CRP significantly correlated with physic
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