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Anthropometric measures and dietary assessment will be performed as well. Data analysis will be done using SPSS version-21 software. The interest in natural and functional food products has increased globally. This RCT will add to the growing literature for the potential antihypertensive, lipid-lowering, and anti-inflammatory effects of barberry in humans. ClinicalTrials.gov (NCT number) NCT04084847 . Registered on 10 December 2019. ClinicalTrials.gov (NCT number) NCT04084847 . Registered on 10 December 2019. The COVID-19 pandemic has i