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Although 82% of the cerebrospinal fluid (CSF) is localized in the subarachnoid space, the function of the blood-arachnoid barrier (BA has not been elucidated. We found an abundance of drug efflux transporter proteins in the BAB. Moreover, several transporter proteins, including organic anion transporters and organic cation transporters have been found in the BAB. Significant in vivo transport activity of the BAB has been observed, suggesting that the BAB plays a pivotal role in the CNS barrier. Using quantitative targeted absolute prot
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