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Medication For ADHD - What Are the Side Effects? Many people with ADHD have their symptoms improved through medication. But each person reacts differently to different medications and side effects can be troublesome. Methylphenidate is a stimulant. It works by increasing levels of a brain chemical that helps regulate the behavior and focus. Stimulant drugs Stimulant medication can improve attention and concentration for 70% to 80% children and adults that take it.