https://www.selleckchem.com/pr....oducts/bgj398-nvp-bg
This has broad implications for understanding gating mechanisms of EAG, and related ERG and ELK channels, and places the PAS domain as a new target for drug discovery in EAG and related channels. Upregulation of EAG channel activity is linked to cancer and neurological disorders. Our study raises a possibility of repurposing the antipsychotic drug chlorpromazine for treatment of neurological disorders and cancer. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.The stringent response
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