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observed, underlying colon cancers should be considered.BACKGROUND Large (≥3 cm) benign thyroid nodules usually cause clinical symptoms or cosmetic concerns and therefore require treatment. Microwave ablation (MWA) is a potential valid non-surgical treatment alternative, but there is a lack of evidence. Thus, this study is to evaluate the safety and efficacy of MWA in the treatment of large benign thyroid nodules. METHODS A retrospective study was conducted on 42 large benign thyroid nodules in 40 patients treated with MWA. We used the