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The most important protease (Mpro) of SARS-CoV-2 is considered a promising target, centered on earlier outcomes from associated CoVs with lopinavir (LPV), an HIV protease inhibitor. However, restricted research is out there for other medically authorized antiretroviral protease inhibitors. Substantial use of atazanavir (ATV) as antiretroviral and past evidence suggesting its bioavailability within the respiratory system caused us to examine this molecule against