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Notably, no expansion of pancreatic acinar cells, such as that seen after management of T3 or perhaps the TRβ agonist GC1 ended up being detected after either TG68 or IS25, demonstrating the hepato-specificity among these novel TRβ agonists. CONCLUSIONS The current research implies that TG68 and IS25 induce massive hepatocyte proliferation without overt toxicity. Hence, these agents might have a significant clinical application for regenerative treatm