https://www.selleckchem.com/pr....oducts/LY2228820.htm
Clearance decreases through childhood and higher infusion rates in children would achieve target concentration rapidly without the need to titrate initial infusion rate. An infusion rate of 4.5mgh kg in a 10kg infant, 4mgh kg in a 20kg child and 3.5mgh kg in a child 30-40kg will target an activated clotting time slower than 400s. Adult regimens could be used in those children heavier than 50kg. Bivalirudin infusion in children should be started after loading dose at rates greater than those used in adults. Dose in neonates remains unc
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