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Longevity is a complex process controlled by both environmental and genetic factors. We evaluated the association of four cytokine gene polymorphisms with longevity in an Italian cohort. A sample of 1019 subjects aged 10 to 100 and belonging to the North-Italian population was genotyped for IL-6 (GC, rs1800796), IL-10-1082 (GA, rs1800896), TNF-α-308 (GA, rs1800629), and TGFβ1 codon 10 (TC, rs1800471) gene polymorphisms. The association between cytokine gene polymorphisms and longevity was evaluated by dividing the samp