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For patients on prolonged mechanical ventilation (PMV; 21 days), successful weaning has been attributed to various factors. The aim of this study is to determine the usefulness of the rapid shallow breathing indeRSBI) and other potential predictors of successful weaning in patients unable to wean and requiring extreme PMV at a hospital-based long-term ventilator facility in Israel. Material and ethods Retrospective analysis of prospectively collected data over 5 years. A total of 150 subjects on PMV, ready to undergo a weaning proc