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Right here, we report a comparative research of hepatic spheroids produced from newly isolated mouse whole liver cells (WLCs) and HCs (called SphWLC and SphHC, correspondingly). We found that HC differentiation was maintained better in SphWLC compared to SphHC, and, when co-cultured with liver cyst spheroids (SphT), SphWLC showed stronger suppression of SphT development compared to SphHC. Histological characterization disclosed marked activation and accumulation of hepatic stellate cells (HSCs) during the SphWLCSph
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