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No effects of living in isolated MSAs were found for those with at least a high school education, but older adults with less than a high school education had lower cognitive function in MSAs with greater isolation (b=-0.274, p0.05). The degree of dissimilarity was not associated with cognitive function. The association between segregation and cognitive function did not vary by race. Metropolitan segregation was associated with lower cognitive function among older adults, especially for those with lower education living in racially