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29, P less then 0.001) and PFS(HR 0.39, P less then 0.001). HAIC caused more grades 3-4 neutropenia (HR 10.71), anemia (HR 7.55), leukopenia (HR 10.38), and thrombocytopenia (HR 13.09) than SORF. However, HAIC caused fewer cases of grades 3-4 aspartate aminotransferase rising (HR 0.21), diarrhea (HR 0.14), and hand-foot syndrome (HR 0.14) than SORF. CONCLUSIONS This systematic review demonstrated that HAIC is superior to SORF in HCC with PVTT with respect to OS, PFS, and DCR, especially in HCC with types III-IV PVTT. HAIC caused more my
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