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process, which may also enhance early diagnosis and enable disease staging in sCJD.Purpose of review In this review, we will discuss treatment interventions targeting drivers of immune activation and chronic inflammation in PWH. Recent findings Potential treatment strategies to prevent the progression of comorbidities in PWH have been identified. These studies include, among others, the use of statins to modulate lipid alterations and subsequent innate immune receptor activation, probiotics to restore healthy gut microbiota and